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Covid-19 : MedCram

Posted by CliffStamp 
Covid-19 : MedCram
June 01, 2020 09:44AM
This series is based on the LITERATURE/SCIENCE not blogs, opinion, propaganda :

Video #1 :

[www.youtube.com]

-started in 2019, Wuhan China, animal market
-already spread out of China
-RNA virus, lots of corona-viruses
-this one has jumped from animal -> human, mutation to allow binding to human proteins
-close contact, eating
-the virus can replication inside people, IF it can spread from person to person, possibly an epidemic
-seen before in SARS (bats), MERS (camels)

If you want actual information out there, like/share and spread these video's. I will be posting up summaries of all of them here as time allows.
Re: Covid-19 : MedCram
June 01, 2020 01:30PM
Video # 2 :

[www.youtube.com]

-41 patients (Wuhan) symptoms : fever(98%), cough, shortness of breath (virus positive confirmed through molecular analysis)
-8 days to develop the shortness of breath once symptoms started
-29% developed ARDS (that's the lung disease)
-15% fatality rate (1 death with no comorbidities, 2%)

A few key points :

-he already recommends restrictions to/from Wuhan (this was not followed, Trump was later called racist for suggesting travel restrictions)
-that huge fatality rate is likely one of the main factors in the insane fear that followed

Note here that since they are only looking at people who are seriously ill (go to the hospital) the complication and fatality rates are highly exaggerated. For comparision here (Canada, 2018/19)

-for those hospitalized for the flu, 8% of them were fatal
-for those in ICU for the flu, 50% of them were fatal

[www.canada.ca]
Re: Covid-19 : MedCram
June 01, 2020 03:20PM
#3 :

[www.youtube.com]

-first modeling, 90% containment -> 59, 000 people infected, 50% containment -> 5, 000, 000 infected
-growing concern about asymptomatic spread, China refuses to releases data on this to study (US)
-first case in Toronto (from Wuhan)
-still no evidence of human to human transmission outside of China
-vaccines could be ready in 3-months (NIH)
-focus on ARDS (lung inflammation as the main concern)
Re: Covid-19 : MedCram
June 01, 2020 05:04PM
#4

[www.youtube.com]

-ARDS, lung inflammation, prevents oxygen, requires ventilator
-use high pressure, low tidal volume to prevent shear stress on the aveloi
-in extreme cases may require paralysis of the patients (low tidal volume feels like you are not getting enough air)
-patients in a prone position (flipped, belly down), cuts mortality in half
Re: Covid-19 : MedCram
June 01, 2020 06:02PM
#5 :

[www.youtube.com]

-mortality rate, 2.2 - 2.3%, however care to be taken that these are indeed covid-sars-2
-if there is a large amount of asymptomatic cases, this number could be far lower
-china is building a huge hospital, 10, 000 beds
-human to human transmission outside of China, carrier was asymptomatic
-comparison of the flu, more deaths in California to covid-19 worldwide
Re: Covid-19 : MedCram
June 02, 2020 07:57AM
#6

[www.youtube.com]

-clear again that lack of tests mean the fatality rates are very uncertain
-asymptomatic spreading a growing concern for screening (travel, etc.)
-it appears that there is a difference between how it effects the young (mild) vs the old (severe)
Re: Covid-19 : MedCram
June 02, 2020 08:04AM
#7

[www.youtube.com]

-still concerns about the fatality rates being calculated during an ongoing epidemic, only will be accurate once it is over
-asymptomatic cases could cause the mortality rate to be grossly over estimated
-passed SARS in terms of cases
-started to quarantine people in the states who test positive and restrict travel
-incubation period seems short, mainly happens in a few days
-growing evidence you are infectious during and after showing symptoms
-raise concerns immediately about the concerns of long term quarantine on infected individuals, even though it is safer for everyone else
Re: Covid-19 : MedCram
June 02, 2020 07:44PM
#8 :

[www.youtube.com]

-start of the standard 14 day quarantine for travel travel in from China, restriction to three airports
-one death outside of China
-ARDS -> recover -> OI's (secondary infection, stapf is very common/MRSA)
-novel corna virus seems to me more infective/deadly than the regular flu
Re: Covid-19 : MedCram
June 02, 2020 07:48PM
#9 :

[www.youtube.com]

-incubation period, mean is ~5.2 days, 95% < 13 days
-criteria for discharge, 10 days no fever, no virus in URT, chest x-ray show improvement
-15% mortality rate for those hospitalized
-a doorknob has the virus detected on it
-how it spreads, may have underestimated fecal/oral route
Re: Covid-19 : MedCram
June 03, 2020 10:48AM
#10 :

[www.youtube.com]

-calculate the RO to be 2-3 (reproduction number, based on assuming a similar SI to SARS/MERS and calculated to fit the reporting data)
-second death outside of china
-patient in US/Washington released to home isolation
-concern about public bathrooms/restrooms
-avoid public bathrooms, wash hands, avoid touching surfaces
-close the toilet before you flush
-carry/use hand sanitizer
-MuLBSTA Score (to predict mortality)
-relation to HIV, not based on science
Re: Covid-19 : MedCram
June 03, 2020 11:58AM
#11 :

[www.youtube.com]

-testing in the US moved from CDC to local labs
-Remdesiver, SARS/MERS, works invitro, starting compassionate use
-Chlorquine, alters the Ph and lysome function
Re: Covid-19 : MedCram
June 03, 2020 12:03PM
#12 :

[www.youtube.com]

-concern about data from China, are they intentionally providing lower cases
-ACE2, an enzyme on the outside of cells, the target for the new corona virus
-first warning that smokers might be at higher risk do to a higher ACE2 expression
-more links to bats
Re: Covid-19 : MedCram
June 03, 2020 01:27PM
#13 :

[www.youtube.com]

-first sign that cases may be leveling
-comparison to the FLU, already 20 million in the US, 10, 000 deaths
-canada, cases in Vancouver (travel to Wuhan), first person to person tranfer in Canada
-again youth/healthy have little impact
Re: Covid-19 : MedCram
June 03, 2020 09:18PM
#14 :

[www.youtube.com]

-WHO is allowed to enter China
-study on 138 patients hospitalized, fever in 99% of people (hence why thermometers can screen)
-25% went to ICU
-6 died
-recommend N95 masks/eyecare protection for health care providers
-patients wear regular masks
Re: Covid-19 : MedCram
June 05, 2020 07:48PM
#15 :

[www.youtube.com]

-stress again, the numbers have to be taken with caution
-china's hospitals are over whelmed, expanding / building hospitals
-median incubation period ~3 days, new study
-larger study, 1000+ people, ~5% serious (ICU), ~1% fatality
-the difficulty of lack of random/pleacbo trials to get working medications
-use treatments we know for ARDS
-try medications which are questionable benefit, but low risk, compassionate use (patients in extreme situations)
cKc
Re: Covid-19 : MedCram
June 06, 2020 02:29AM
interesting data, and i guess a little bit historical as this is going stage by stage as it occured.

----------------------------------------------------------------------
It's not Cliff, its Dr Stamp
#kebabstickcut, it's a thing - make it happen
Re: Covid-19 : MedCram
June 06, 2020 02:28PM
#16 :
[www.youtube.com]

-covid-sars-2 is the name of the virus
-basic virus reproduction explanation
-basic immune response to a viral infecting cell
-focus on inhancing your immune system
-sleep is the most important thing you can do to bolster your immune response to viruses
-recommended 7-9 hours a sleep, ~60% get that much
-the main region for immune boosting is the 9/10 - 12 at night
-the danger of electronics/light -> eyes pushing your sleep cycle back
Re: Covid-19 : MedCram
June 06, 2020 06:05PM
#17

[www.youtube.com]

-positive cases/deaths are being classified by symptoms vs PCR (+50% increase overnight due to a much more relaxed definition/classification)
-discussion of how to get proper sleep
-Van Cauter study, takes ~20 days of extended sleep to get your immune system up to normal, after just four days at 4 hours
-even after ten days of extended sleep (+12 hours), the group sleep deprived in the first 4 days had HALF the immune response
-Cohen study, 153 people, < 7 hours of sleep, on average 3 times as more likely to develop a cold when exposed to the virus
-even worse for efficiency, people who are in bed but not asleep (>10% of the time), ~5x as likely to get the cold
-in short, don't get in bed until you are going to sleep, get 8+ hours of sleep
Re: Covid-19 : MedCram
June 06, 2020 07:26PM
#18

[www.youtube.com]

-clinical cases are now almost as much as tested cases (that is symptom case classification)
-retraction of early paper about asymptomatic transmission, turns out the individual was symptomatic she just didn't report it
-phone tracking in China, tracks where you have been
-again the importance of sleep, rules to follow for proper sleep
Re: Covid-19 : MedCram
June 06, 2020 07:30PM
#19 :

[www.youtube.com]

-80 trials launched on treatments for covid-sars-2
-need for double blind studies
-get vaccinated for the FLU, flu cases are rising and are serious
cKc
Re: Covid-19 : MedCram
June 06, 2020 08:33PM
Quote
CliffStamp
-sleep is the most important thing you can do to bolster your immune response to viruses
-recommended 7-9 hours a sleep, ~60% get that much
-the main region for immune boosting is the 9/10 - 12 at night
-the danger of electronics/light -> eyes pushing your sleep cycle back

this is where my insomnia gets me.

4-6 hrs a night until I get too exhausted and pass out.
sleep 3-5am - 10am

----------------------------------------------------------------------
It's not Cliff, its Dr Stamp
#kebabstickcut, it's a thing - make it happen
Re: Covid-19 : MedCram
June 07, 2020 08:35AM
#20 :

[www.youtube.com]

-new cases outside of China are accelerating
-false information is rapidly propagating
-first really large study, > 70, 000 people
-vast majority > 80% were mild, the majority of the severe cases are elderly
-no evidence of super-spreaders
-number declining in China, commentary about as people get infected it gets harder for the virus to keep spreading (herd immunity)
Re: Covid-19 : MedCram
June 07, 2020 06:54PM
#21 :

[www.youtube.com]

-discussion of anti-bodies
-looking at immune cells from recovered patients, using mice to replicate/grow these antibodies
-comparison to the flu fatality rate (0.1 for the flu, 2% for covid-sars-2)
-immunity for recovered, rumors of people getting the disease twice (still a rumor)
Re: Covid-19 : MedCram
June 08, 2020 02:26PM
#22 :

[www.youtube.com]

-viral loads in the upper respiratory track, taper off severely after ~14 days
-asymptomatic patients can have similar viral loads as symptomatic
-require asymptomatic testing to fully understand the spread of the virus
Re: Covid-19 : MedCram
June 08, 2020 04:28PM
Since sleep has been mentioned, I find this topic interesting. There is also a TED talk on brain lymphatics with a mouse brain video.
[neuronline.sfn.org]
Re: Covid-19 : MedCram
June 09, 2020 12:24PM
#23 :

[www.youtube.com]

-not all numbers being reported are using the same criteria (testing vs symptoms)
-bats have *hundreds* of corona viruses
-infants < 1 year (9 patients out of 75, 000), no severe complications
-appears that the virus doesn't cross the placental barrier
-studies from three years ago showing bat corona viruses can cross to humans (cultured in lab AND in evidence in native populations)
-warnings from researchers at that time of the potential mass spillover from bats -> people
Re: Covid-19 : MedCram
June 10, 2020 12:52PM
#24 :

[www.youtube.com]

-possible summer/winter dependence
-total mortality rate 1-3% across various countries
-Italy outbreak, 50, 000 people in lockdown (violations -> prison)
-asymptomatic transmission, growing evidence this is possible, no real data on how likely
Re: Covid-19 : MedCram
June 12, 2020 02:50PM
#25 :

[www.youtube.com]

-China vs Italy, both are in lock-down, argue for strict lockdowns to save lives
-it might be a seasonal issue, just like the flu
-importance of sleep/rest for immune response
-clinical trials starting in ~3 months for vaccines
Re: Covid-19 : MedCram
June 13, 2020 06:17PM
#26

[www.youtube.com]

-first discussion of a pandemic classification
-first trial of Remdesivir in the US (an anti viral)
-discussion that the US can NOT close its borders so the virus will spread
-focus on what you can do to get healthy, fight the virus
Re: Covid-19 : MedCram
June 13, 2020 06:23PM
#27 :

[www.youtube.com]

-test sensitivity is 70% (30% chance you are positive, will show negative)
-community spread possible in the US
-PCR isn't as sensitive as chest scan
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